The adult mammalian myocardium has a robust intrinsic regenerative capacity because of the presence of cardiac stem cells (CSCs). Despite being mainly composed of terminally differentiated ...

The central objective of this proposal is to “turn back the clock” of the myocyte cell cycle for myocardial regeneration. Previous research observations of Zhang’s lab suggest that mammalian ...

A variety of preclinical and clinical studies using different cell types have demonstrated variable degrees of improvement in cardiac function in models of acute myocardial infarction (MI ...