Glaucoma is a complex and multifactorial neurodegenerative disorder primarily characterized by the progressive loss of retinal ganglion cells (RGCs) and their axons, leading to irreversible visual ...

Trk activation in the secretory pathway promotes Golgi fragmentation ... Pincher-mediated macroendocytosis underlies retrograde signaling by neurotrophin receptors. J Neurosci. 25(21), 5236-47.

In contrast, downregulated miRNAs were more strongly associated with the signaling of neurotrophin TRK receptors and Toll-like receptor signaling pathways, such as the TRIF-dependent pathway and ...

Targeting mitochondrial retrograde signaling may therefore be promising in the treatment or prevention of metabolic disorders ...

A new study shows how an anticancer drug triggers an "outside in" signal that gets it sucked into a cancer cell. The work, ...

This influx of calcium at the contact site attracts and activates a kinase called CaMKII, a protein known to be important in ...

7 refine our understanding of the signaling effects of oncogenic KRAS. Rather than activating multiple effectors, mutant KRAS signals preferentially through the RAF–MEK–ERK pathway ...

New research shows that a network of subcellular structures similar to those responsible for propagating molecular signals that make muscles contract are also responsible for transmitting signals in ...

GOVERNOR MAURA HEALEY RECENTLY SIGNED IT INTO LAW AS THE PHYSICIAN PATHWAY ACT. A BUSY PRIMARY CARE DOCTOR TAKES CARE OF 1500 TO UP TO 2000 PATIENTS, SO JUST EVEN ONE PERSON GO INTO A COMMUNITY ...