Mitogen-activated protein kinases (MAPKs) – serine/threonine protein kinases involved in inflammation and growth and implicated in chronic pain, cancer, and stress – are a hot topic these days. In the ...

Panel A summarizes the conventional model of how oncogenic ... pathways that may be involved in tumor adaptation to inhibition of the KRAS–RAF–MEK–ERK pathway. Key among these is the ...

Co-opted pathways required by oncogenic KRAS in order to sustain lung tumorigenesis Cytokine signaling and its associated STAT3 and NF-κB activation are required for KRAS-induced tumorigenesis.

One major focus of our lab is the study and development of selective inhibitors of the ERK pathway to treat the tumors driven by ERK hyperactivation. Previously we found that activation of ERK output ...