Published in Cell Reports Medicine, results of a VHIO-led study support the feasibility of using RAD51 testing to complement ...
Published in Cell Reports Medicine, results of a VHIO-led study support the feasibility of using RAD51 testing to complement next-generation ...
In trastuzumab resistant cells, PTEN function is lost; thus, Akt is constitutively active. Also, resistant cells can harbor activating mutations in PI3K or Akt, which can trigger other downstream ...
Collectively, miR-34a plays a vital role in controlling cellular apoptosis, autophagy, inflammation, aging, fibrosis, and remodeling through Smad4/TGF-β1, FOXO3/PUMA, Notch1/ETBR, PTEN/PI3K/SIRT1 and ...
Monoallelic loss of PTEN and ARID1A is identified in normal colonic epithelium. The resulting haploinsufficient phenotypes ...
In patient-derived and animal tumour models, mubritinib suppressed glioblastoma stem cells and tumour growth by targeting ...
Three trials presented at ASCO GI 2025 will change practice and improve the treatment of colorectal cancer, according to experts.
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Most, if not all, of the pathways that are crucial for cancer development and progression affect translational control. These include the selective translation of mRNAs encoding proteins that are ...
Adjuvant treatment with 160 mg aspirin daily for three years cuts recurrence rates in patients with colorectal cancer.