Several studies have shown that insulin-producing pancreatic β-cells of patients with diabetes have abnormal mitochondria and ...

Mitochondria are essential for generating energy that fuels cells and helps them function. Mitochondria are essential for generating energy that fuels cells and helps them function.

require lifelong immunosuppression to prevent rejection of the graft and potential recurrence of the autoimmune process that might again destroy pancreatic islet β-cells. Immunosuppressive ...

Mitochondrial damage is common in metabolic diseases like Diabetes, affecting insulin production and function in patients. Diabetics’ insulin-producing β-cells have abnormal mitochondria, impairing ...

Activation of both endogenous and exogenous ligands of pattern-recognition receptors can induce islet inflammation and death of pancreatic β cells Amplification of insulitis might depend on a ...

(B) Total β-cell area per pancreas for WT animals (n=3) and animals with CF (n=3). (C) Quantification of islet size in WT (n=3) and CF (n=3) pancreas. (D) Frequency distribution of individual ...

Our study found that demethylase TET2 was localized in the islets of mice, and the expression level increased with age. TET2 knockout in pancreatic β cells can hypermethylate PTEN, up-regulate MOF and ...