Targeting of bacterial gyrase, specifically the gyrB subunit, is a promising approach because of this enzyme's essential role in bacterial DNA replication and its absence in higher eukaryotes.

Jumbo phages utilize a complex protein import system, with Imp1 as a key gatekeeper, to transport proteins into their ...

Taking cues from experimentally characterized S/MARs from the eukaryotic genome, several functions, including the initiation of DNA replication ... investigated at the genomic scale in a variety of ...

The nucleus is where eukaryotes store their genetic information. In prokaryotes, DNA is bundled together in the nucleoid region, but it is not stored within a membrane-bound nucleus. The nucleus is ...

Researchers have revealed new details about the CRISPR-Cas5-HNH/Cascade complex, a variant of the type I-E CRISPR-Cas system, ...

Protein synthesis is vital for life, translating genetic information from DNA to functional proteins through transcription ...

The high accuracy or fidelity of semi-conservative DNA replication is the product of nucleotide template interaction, polymerase-enhanced base selectivity, exonuclease proofreading and the post ...

Eukaryotic cell DNA in a nucleus, plasmids are found in a few simple eukaryotic organisms. Prokaryotic cell DNA is a single molecule, found free in the cytoplasm; additional DNA is found on one or ...

DNA replication is happening continuously throughout the body, as many as trillions of times per day. Whenever a cell divides -- whether to repair damaged tissue, replace old cells, or simply to ...

This important study presents compelling observational data supporting a role for transcription and polysome accumulation in the separation of newly replicated bacterial chromosomes. The study is ...

Comparison of that ancient DNA with modern human DNA showed that the two species had interbred and that people today still carry the genetic fingerprint of that intermixing. Since then ...