Researchers at the Harvard Medical School discovered that the enzyme GUK1 promotes lung cancer growth by boosting the ...

The mechanism of enzyme catalysis is similar in principle to ... which involves cholesterol and vitamin K. Protein kinase R-like endoplasmic reticulum kinase-phosphorylated adenylosuccinate ...

On the other hand, mechanisms of acquired resistance to 'pathway-targeted' drugs, such as the various clinically active kinase inhibitors, have been somewhat more straightforward to elucidate and ...

Background: UCK2 (Uridine-Cytidine Kinase 2) is a promising prognostic marker for malignant ... This study aims to shed light on the role and possible mechanism of UCK2 in pan-cancer. Methods: We used ...

Another focus is to understand the interplay between protein phosphorylation and protein ubiquitylation ... to commercialise the MRC PPU’s phosphorylation reagents and also the kinase profiling ...

The researchers investigated the effect of different conducting polymers (PANI, PPy, and poly(3,4-ethylenedioxythiophene) (PEDOT)) on the mechanism of CP@CdS core-shell nanorods. The results show that ...

"The addition of water alters the reaction mechanisms, promoting pathways that enhance catalytic activity while suppressing coke formation," explains Dr. Ro. "This dual role improves process ...

"These findings illuminate a critical mechanism that connects local synaptic ... This research focuses on the cAMP-response element binding protein (CREB), a transcription factor known to regulate ...

The lab recently determined that what is important is not formation of the fusion, but that the formation results in an increase of the amount of PRKACA—the catalytic subunit of protein kinase A ...

Given that proteins display large ... entropic bottleneck for enzyme catalysis. To shed light on this question, we studied the nature of the enzymatic transition state for the phosphoryl-transfer step ...

Get Instant Summarized Text (Gist) Artificial motors have been developed to mimic muscle proteins, converting chemical energy into mechanical work. These nanoscale rotary motors, embedded in ...