Sustained exposure to pathological stress stimulates the heart to hypertrophy ... Cyclic GMP and protein kinase G (PKG) are intrinsic brake systems inhibiting several hypertrophic cascades.
This process governs the contractile power of the heart, and might undergo progressive dysregulation in cardiac hypertrophy ... levels of G-protein-coupled receptor kinase 2 (GRK2) — a kinase ...
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