Similarly, APP lysine lactylation (APP-Kla) was markedly lower in 6-month-old APP23/PS45 AD mice than in wild-type controls. Further, in HEK293 cells overexpressing APP with familial AD mutations, APP ...

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Figure 1. Cyclic Rho GTPase modulation, functions, and TRP channel-mediated regulation hypothesis. Rho GTPases cycle between an active form bound to GTP (blue arrows) and an inactive form that is ...

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