A thermal stability-based proteomic analysis identifies cytoplasmic PEBP1 as a mediator of mitochondrial dysfunction-induced stress response, highlighting its potential role in cellular adaptation ...
The studies suggest that mutant KRAS signals predominantly through the rapidly accelerating fibrosarcoma (RAF ... related kinase (ERK). AF6 denotes afadin, GAP GTPase-activating protein, GEF ...
In October 2024, Lutris successfully completed enrollment in the international phase 2 trial of LUT014 in patients with metastatic colorectal cancer (mCRC) treated with EGFRi therapy who develop ...
B-Raf is a protein encoded by the BRAF gene and is a ... eliciting downstream phosphorylation and activation of the MAP Kinase pathway. Drugs called EGFR inhibitors can block the EGFR signal ...
zju.edu.cn Objective Raf kinase inhibitor protein (RKIP) appears to control cancer cell metastasis and its expression in colonic tissue is related to colonic cancer development. We sought to identify ...
These names in the biotech sector are seeing a substantial increase in search activity today, as determined by InvestingChannel. They ...
Upstream reactivation of associated proteins such as Aurora Kinase A (AURKA), a serine/threonine kinase ... by stabilizing the interaction between newly formed KRASG12C protein and RAF, thus aiding ...
The mitogen activated protein kinase (MAPK) are serinethreonine kinases activated by phosphorylation catalyzed by MEK, the MAPK kinase. MEKs are phosphorylated and activated by the RAF protein kinases ...
In addition, HER2 activation can activate Ras/Raf and MEK pathways, which favors cancer cells ... ADCC, antibody-dependent cellular cytotoxicity; Akt, protein kinase B; c-Cbl, Casitas B-lineage ...
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