Because SGLT2 inhibitors act on the kidney, and the amount of glucose excreted is closely dependent on the glomerular filtration rate (GFR), it can be anticipated that SGLT2 inhibitors will have a ...

SGLT2 inhibitors are a new family of agents ... Canagliflozin; eGFR Estimated glomerular filtration rate; FPG: Fasting plasma glucose; PPG: Post prandial glucose; SITA: Sitagliptin; TIIDM ...

Investigators compared the outcomes of patients with type 2 diabetes who continued versus stopped metformin after progressing to stage 4 chronic kidney disease.

The dual SGLT1/2 inhibitor sotagliflozin (Inpefa) reduced the risk for myocardial infarction (MI) and stroke in high-risk ...

sodium-glucose transporter 2 (SGLT2) inhibitors — these reduce the amount of glucose reabsorbed by the kidneys, meaning that it is excreted in the urine. A meta-analysis, published in the ...

Opens in a new tab or window Comparative effectiveness study followed adults with type 2 diabetes who initiated SGLT-2 inhibitors from 2014 to 2020. Real-world outcomes largely point to comparable ...

Lexicon Pharmaceuticals has reported that LX4211, an inhibitor of the sodium-dependent glucose transporter 2 (SGLT2; also known as SLC5A2), significantly improved glycaemic control in a Phase II ...

The SGLT2 inhibitors, as a class, lead to similar treatment benefits at comparable clinical doses, although there are some discrepancies between them, particularly when dapagliflozin (Farxiga; ...

The effects of SGLT2 inhibitors on the kidney to prevent ... Participants were at high risk for progression with estimated glomerular filtration rate of 25 mL/min/1.73 m 2 to 75 mL/min/1.73 ...