As the basic unit of life, cells utilize signaling pathways to receive inputs ... of modeling sarcomagenesis using multipotent mesenchymal stem cells (MSCs) and discuss common mechanisms of ...

This important study focused on characterizing clonally derived MSC populations from the synovium of normal and osteoarthritis (OA) patients, demonstrating their potential to regenerate cartilage in ...

Graft-versus-host disease (GVHD) is a common and severe complication that occurs after stem cell transplantation, where the ...

We were the first lupus organization in the U.S. to support stromal cell research. In partnership with the National Institute of Allergy and Infectious Diseases, we committed nearly $4 million over ...

In an initial study, the researchers developed a gelatin-coated polyamide mesh that was either seeded or not with labeled human endometrial mesenchymal stem cells (eMSCs). 15 In a rat model of wound ...

Mesenchymal stem cells are adult stem cells found in several places in the body, including in the bone marrow, skin, and fat tissue. For over a decade, smaller clinical trials have explored the ...

This research highlights the use of exosomal miR-4645-5p from hypoxic bone marrow mesenchymal stem cells ... the MAPKAPK2 pathway, thereby regulating the AKT-mTORC1 signaling cascade.

Periostin also enhanced mesenchymal stem cell and macrophage migration and endowed macrophages with tumor-associated macrophage-like properties. Thus, CAF-secreted periostin contributed to tumor ...

Collectively these molecular pathways direct intracellular signaling cascades that regulate the migration ... The composite scaffolds produced by our group support robust mesenchymal stem cell ...

More information: Barbara Klein et al, Modified human mesenchymal stromal/stem cells restore cortical excitability after focal ischemic stroke in rats, Molecular Therapy (2024). DOI: 10.1016/j.ymthe.

China's top drug regulator has recently approved the nation's first stem cell therapy to treat ... The homegrown therapy is the first mesenchymal stromal cell treatment that has gained the ...