Researchers are enhancing the best features of AAV capsids and overcoming their limitations to accelerate gene-based therapies.

Thus, enzymes modified to contain protein transduction motifs may represent a general strategy for improving the distribution of secreted proteins following in vivo gene transfer. Figure 2 ...

Optogenetic technology was used to manipulate intracellular signal transduction, revealing how periodic cAMP signal frequencies regulate gene expression and cell fate determination.

A research team led by Dr. Tetsuya Muramoto from the Faculty of Science at Toho University has demonstrated the mechanisms by which periodic chemical signal frequencies in cells regulate gene ...

Wrana, Hospital for Sick Children, Toronto, Ontario, Canada, and department of medical genetics and microbiology ... is one thing that is known about the mechanisms that govern signal transduction, it ...

The signal transduction pathways of mitogen-activated protein (MAP) kinases have been actively studied for some time. About three years ago, a new mammalian protein kinase encoded by the gene p38 was ...

Researchers have identified a method to enhance the effectiveness of a promising cancer treatment. They found that modifying ...

With the strong associations established in epidemiologic studies and a dearth of evidence on the actual mechanisms by which ...

Data on mRNA vaccines sent by Moderna to European regulators before the COVID-19 outbreak included early tests of the mRNA ...