A defining duo of the first Donald Trump administration is back.

Sen. Lisa Murkowski announced Thursday that she will vote against confirming Pete Hegseth to lead Pentagon, becoming the first Republican to oppose one of President Donald Trump's Cabinet picks.

Sen. Lisa Murkowski, R-Alaska, said on Thursday she can't support Pete Hegseth to be President Donald Trump's secretary of Defense.

Republicans say they are confident that Hegseth, who has been accused of alcohol and domestic abuse, will ultimately be confirmed to lead the Pentagon.

WASHINGTON (AP) — Sen. Lisa Murkowski won't support Hegseth to lead Pentagon, becoming the first Republican to oppose a Trump Cabinet pick.

The Alaska Republican plans to vote against the confirmation of Pete Hegseth to lead the Department of Defense.

GOP Sen. Lisa Murkowski says she "cannot in good conscience" support Pete Hegseth for secretary of defense, and Sen. Susan Collins voted "no" on his nomination in a procedural vote.

Sen. Lisa Murkowski won't support Hegseth to lead Pentagon, becoming the first Republican to oppose a Trump Cabinet pick.