Adeno-associated virus 2 (AAV)-based vectors have gained ... cell surface expression of HSPG alone is insufficient for AAV infection, and that AAV also requires human fibroblast growth factor ...

This approach uses co-infection with a transgene-containing ... expression of more than 600-fold from a minimal simian virus 40 (SV40) promoter and an increase in expression of 200-fold from ...

Recombinant adeno-associated viruses (AAVs) are ideal gene delivery vehicles that have the potential to treat a variety of diseases. Because they do not replicate without a helper virus, AAVs alone ...