Furthermore, Akt and MAPK status was frequently different ... tyrosine kinase inhibitors targeted downstream of the EGFR signaling pathway could theoretically prove more effective than anti ...

Rather, several distinct signaling mechanisms appear to contribute to GPCR-mediated MAPK activation. These include transactivation of the Epidermal Growth Factor Receptor (EGFR) via the autocrine ...

"With the addition of VS-7375, a potential best-in-class oral KRAS G12D (ON/OFF) inhibitor, we are well-positioned to further establish our leadership in targeting RAS/MAPK pathway-driven cancers ...