Aberrant activation of the Ras/Raf/MAPK/ERK kinase/extracellular signal-regulated kinase cascade and the VEGF pathway are commonly observed in breast cancer cells leading to malignant cell ...

Its effect on cancer growth will take some explanation. An important cellular pathway is the mitogen-activated protein kinase (MAPK) pathway ... and intensity of ERK signaling, which is crucial ...

we are well-positioned to further establish our leadership in targeting RAS/MAPK pathway-driven cancers, including metastatic pancreatic cancer, non-small cell lung cancer, and KRAS G12D mutant ...