leading to the activation of A1 astrocytes and M1 microglia and elevated neuroinflammatory cytokines. The disruption of this crosstalk between IL-3 and IL-3Rα induces lipid metabolic ...
Stationed within the meninges, squads of immune cells lie in wait, ready to unleash an inflammatory assault within the brain if needed. Holding these trigger-happy troops back during peacetime falls ...
A new study published in Brain, Behavior, and Immunity has found that inflammation in a key memory center of the brain can ...
Wildfire smoke, long recognized as a health threat to the lungs and heart, may also pose significant risks to brain health, according to a study published in the International Journal of Molecular ...
Hyperglycemia leads to the activation of astrocytes. These activated cells produce proinflammatory mediators like cytokines or chemokines, that cause cerebrovascular damage. Previous sequencing showed ...
Experimental models have revealed that these cytokines promote astrocyte and microglial reactivity ... stress hormone levels—have been shown to promote chronic priming and activation of microglia, ...
Most neuroscience research carried out up to date has primarily focused on neurons, the most renowned type of cell in the ...
In patient-derived and animal tumour models, mubritinib suppressed glioblastoma stem cells and tumour growth by targeting ...
2019). In macrophages, this activated homeostatic genes involved in wound healing. Beyond histones, lactylation has been identified on a variety of proteins, including enzymes, transcription factors, ...
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and suppressed levels of secretory IgA in saliva are found simultaneously with high levels of circulating proinflammatory and anti-inflammatory cytokines. The underlying mechanisms are multifactorial ...