Over the past two decades, the idea of targeting transcription factors to combat malignancies has turned into a clinical reality.

Internal tandem duplication (ITD) mutation in Fms-like tyrosine kinase 3 gene (FLT3/ITD ... increase in aerobic glycolysis through AKT-mediated upregulation of mitochondrial hexokinase (HK2 ...

In cancer-associated cachexia, elevated TNF-α and IL-6 exacerbate muscle and fat loss by regulating multiple metabolic signaling pathways, which could be ameliorated by Z526's suppression of NF-κB ...

The serine/threonine kinase AKT is a key component of the PI3K/AKT/mTOR signaling pathway as it exerts a pivotal role in cell growth, proliferation, survival, and metabolism. Deregulation of this ...

Relay Therapeutics' financial stability is strong, but zero Q3 2024 revenue and rising net losses raise concerns. Find out ...

Researchers investigate the underlying mechanisms of endothelial insulin resistance involved in obesity-associated diabetes.

Physical activity is not only important for fitness, but also for health. This is confirmed by a new study conducted under the direction of Prof. Dr. Maximilian Kleinert at the German Institute of ...

^UTRECHT, Niederlande und CAMBRIDGE, Massachusetts, Feb. 05, 2025 (GLOBE NEWSWIRE) -- ?New England Journal of Medicine" veröffentlicht: Wirksamkeit von Zenocutuzumab bei NRG1-fusionspositivem Krebs UT ...

One of these proteins is pantothenate kinase 4 (PanK4 ... places it alongside established key players like mTOR, AMPK, and Akt. Targeted modulation of PanK4 could potentially improve metabolic ...