The EMBO Journal1d
The MAST kinase KIN-4 carries out mitotic entry functions of Greatwall in C. elegans
Greatwall, a conserved MAST-like kinase with crucial mitotic entry functions, is curiously absent in worms. Here, the single ...
eLife1d
Identification of nonsense-mediated decay inhibitors that alter the tumor immune landscape
Inhibition of nonsense-mediated decay turns immunologically cold tumors hot by increasing the amount of mutant RNA leading to an increase in T-cell-targetable neoantigens on the cell surface.
themarijuanaherald3d
Study Finds “Cannabinoids Hold Significant Potential for Preventing and Treating Brain Diseases”
According to a new study published in the journal Cellular Signalling, cannabinoids may play a crucial role in preventing and ...
Medindia5d
MYCN and MDM2: A Transformative Strategy in Cancer Therapy
Over the past two decades, the idea of targeting transcription factors to combat malignancies has turned into a clinical reality.
appliedclinicaltrialsonline5d
Zenocutuzumab Shows Durable Efficacy in NRG1 Fusion-Positive Cancers in Phase II eNRGy Trial
The Phase II eNRGy trial showed durable antitumor activity with zenocutuzumab (Bizengri) in patients with NRG1 ...
Frontiers20d
Comparative safety profile of tyrosine kinase inhibitors in NSCLC: a network meta-analysis of hypertension and thrombotic risks
Background: This study examines the risks of hypertension and thrombotic events in NSCLC patients treated with Tyrosine Kinase Inhibitors (TKIs). Objective: To compare the safety profiles of TKIs used ...
C&EN21d
Vitamin B6 Alleviates Aflatoxin B1-Induced Impairment of Testis Development by Activating the PI3K/Akt Signaling Pathway
College of Life Sciences, Key Laboratory of Animal Reproduction and Biotechnology in Universities of Shandong, Qingdao Agricultural University, Qingdao 266109, China ...