and granzyme B but which did not express TRBC1 chain (a marker for expression of a T-cell antigen receptor constant beta chain; uniform positivity or negativity indicates clonality) or CD8.

Recognition of specific antigen through the B-cell receptor (BCR) stimulates the activation ... of encountering cognate antigen 3. The T-cell zone, or paracortex, which is adjacent to the ...

Researchers found that bioengineered CAR-T cells when mixed with other immune cells can "donate" proteins, suggesting ...

Scientists have progressed from merely provoking an anti-cancer immune response to designing it ...

Chimeric antigen receptor T cells (CAR-T) cell therapy has shown promise ... and kill hybridoma cells and RA patient-derived autoreactive B cell subsets from RA patients via recognition of ...

Traditional immunotherapies mainly focus on αβ T cell-based strategies, which depend on MHC-mediated antigen recognition ... Figure 1. Major receptor-ligand recognition between Vδ2/Vδ1 T cells and ...

CD19-directed chimeric antigen receptor (CAR) T-cell therapy, originally developed for haematological malignancies, has recently emerged as a promising therapy for patients with autoimmune diseases.

Communication between MKs and other immune cells is a key aspect of their immune function. MKs secrete cytokines that influence B cell ... pathogen recognition, phagocytosis, and antigen presentation.

Toll-like receptors (TLRs) are well-defined pattern recognition receptors ... the activation of antigen-presenting cells and key cytokines. Furthermore, recent studies also have shown that TLR ...

4 Institute of Pathology and Comprehensive Cancer Center EMN, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Uniklinikum Erlangen, Erlangen, Germany Objectives CD19-targeting chimeric ...