In addition, it is reported to activate a depolarizing inward sodium current that is sensitive to the calcium channel blocker (CCB) nifedipine in isolated human atrial myocytes. It has been ...

Increased activity of the ryanodine receptor Ca release channel was found in atrial myocytes of patients with poAF and a novel mouse model of poAF. Our data suggest that enhanced RyR2 activity is ...

Uhl’s anomaly (a.k.a. “Parchment Heart”) is a rare congenital heart condition where the myocytes are absent ... the tricuspid valve and creating an atrial septal defect, effectively ...

Changes in atrial structure and function in disease may predispose the heart to AF. By recording electrical activity from isolated single cardiac myocytes and from excised perfused intact hearts, we ...

Specific projects include studies on the mechanistic basis of atrial fibrillation ... Cardiac arrhythmia mechanisms are studied in tissue samples and cardiac myocytes isolated from patients and large ...