Cell death is achieved by two fundamentally different mechanisms: apoptosis and necrosis. Apoptosis is dependent on caspase activation, whereas the caspase-independent necrotic signaling pathway ...

For example, Notch signalling is active at very high levels in human t-cell lymphoblastic leukemia, Necakov says, and turning off the Notch pathway in this case, and in other types of cancer, “shuts ...

They also showed that therapeutically targeting this pathway could boost TLSs in tumors ... They discovered that a cell-signaling molecule (or cytokine) called interleukin-33 (IL-33) caused ...

In their latest study, published in Nature, the team used mouse models of pancreatic cancer to identify a new molecular pathway that ... They discovered that a cell-signaling molecule (or cytokine ...

Furthermore, cellular senescence, driven by DNA damage and disrupted cell cycle regulation ... activated protein kinase (AMPK) signaling pathways, which disrupted mitochondrial dynamics and ...

(which the immune system had not previously noticed), signalling that the cancer needs to be destroyed. Prof Cesare credits these breakthroughs to live cell microscope technology that enabled his team ...

Single-cell sequencing reveals cGMP and cAMP signalling pathway dysregulation as the predominant pathway alterations in CHIP mutations Research suggests that CHIP mutations manifest predominantly as ...