Complement in mammalian plasma recognizes pathogenic, immunogenic and apoptotic cell surfaces, promotes inflammatory responses and marks particles for cell lysis, phagocytosis and B-cell stimulation.

To prevent bystander damage to host cells, complement is rapidly inactivated ... and thereby successfully shields itself from ...

Daratumumab binds to CD38 and inhibits the growth of CD38 expressing tumor cells by inducing ... linking as well as by immune-mediated tumor cell lysis through complement dependent cytotoxicity ...