Extraembryonic trophoblast lineages constitute the placenta, and are essential for individual development. In human early embryo development, these cells can be generated from totipotent blastomeres.

Clinical exploitation of in vitro-cultured MSCs has been safely carried out in some human conditions ... and culture conditions. Figure 2: Stromal cells in the haematopoietic-stem-cell niche.

This valuable study presents a mouse gastruloid model that can be used to generate hematopoietic progenitors as well as leukemic cells. However, in its current form, the manuscript is inadequate ...

An innovative organoid model mirrors the pancreas' complexity, generating all three key cell types to explore development and ...

Organoids are 3D cell culture models that more accurately reflect the structural and functional complexities of organs in vitro than traditional 2D cell ... secreting mammary organoids from mouse ...

The long-term co-culture of mouse embryonic stem cells ... of mESC with rat ECs without cell-to-cell contact did not result in the conversion of mESC into ECs. After co-cultivation of adult ...

Breast cancer stem cells are responsible ... for breast cancer therapy. Human breast cancer cell lines (MDA-MB-231, SK-BR-3, and MCF7) and the human embryonic kidney HEK-293T cell line were obtained ...

A University of Ottawa neuroscientist has led a Canadian research team to reveal important new insights into the activation ...

Around 30% of oral cancer cases are caused by human papillomavirus (HPV). By activating a signaling protein called YAP (yes-associated protein, a transcription factor normally involved in stem cell ...

Scientist Sarallah Rezazadeh from the Icahn School of Medicine explores the molecular mechanisms behind adult stem cells as ...

Changes to the intermediate filament (IF) protein, vimentin, were found to promote tumor growth by increasing cancer stemness in an oestrogen independent manner. Targeting vimentin and/or the long ...