In cancer-associated cachexia, elevated TNF-α and IL-6 exacerbate muscle and fat loss by regulating multiple metabolic signaling pathways, which could be ameliorated by Z526's suppression of NF-κB ...

Although the direct role of the MAPK pathway components that mediate AD pathology has ... The authors thank Medical Illustration and Design, part of the Medical Research Support Services of Yonsei ...

Here we report an activity-dependent stabilization of the MAP kinase (MAPK) pathway, prominent in hippocampal dendrites. The longevity of the signal in these dendrites was increased to hours when ...

We reviewed the best free Adobe Illustrator alternatives for managing graphics files without a Creative Cloud subscription. We've rounded-up our top-rated choices for when you want to make the ...

The National Academies of Sciences, Engineering, and Medicine are private, nonprofit institutions that provide expert advice on some of the most pressing challenges facing the nation and world. Our ...

Department of Neurosurgery, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical College, No. 152 Aiguo Road, Nanchang, Jiangxi 330006, China Department of ...

There are two styles to choose from: the default, Animation, which is like a 3D image; and Illustration, which is more flat and cartoony. Apple might add more styles in the future. There's also an ...

Multiple signaling pathways, including Notch, JAK/STAT, NF-κb, and MAPK, regulate macrophage polarization towards the M1 phenotype in RA. Metabolic reprogramming also contributes to this process, with ...

Continued CDK4/6i treatment induces a non-canonical pathway for retinoblastoma protein (Rb ... way ANOVA with Tukey’s post-hoc analysis (**** P < 0.0001). (B) Schematic illustration of live-cell ...

Specifically, hSPAR fulfills its functions by two coordinate pathways: On one hand, hSPAR stabilizes the protein level of P27KIP1 in the cytoplasm by blocking TRIM21-mediated ubiquitin-proteasome ...