The US Food and Drug Administration (FDA) has approved SpringWorks Therapeutics’ Gomekli (mirdametinib) to treat ...

The table below is a review of notable updates that occurred in January 2025 for investigational products in development.

In cancer-associated cachexia, elevated TNF-α and IL-6 exacerbate muscle and fat loss by regulating multiple metabolic signaling pathways, which could be ameliorated by Z526's suppression of NF-κB ...

HealthDay News — For children with severe hypertrophic cardiomyopathy caused by gain-of-function RAS/mitogen-activated protein kinase (MAPK) mutations (RASopathy), trametinib reduces mortality and ...

Learn more. Please also consider subscribing to WIRED It's totally understandable if you haven’t opened Apple Maps since its disastrous launch in 2012, which among other things saw people ...

AF6 denotes afadin, GAP GTPase-activating protein, GEF guanine exchange factor, MEK mitogen-activated protein kinase kinase, MT mutant, Pi inorganic phosphate, P13K phosphoinositide 3-kinase ...

Introduction: Bryostatin-1, a potent agonist of the protein kinase C, has been studied for HIV and ... RNA-seq revealed that mitogen-activated protein kinases (MAPK) 11 was significantly downregulated ...

Get Instant Summarized Text (Gist) A three-drug cocktail has been identified to enhance CAR-T cell therapy by preserving T-memory stem cells (T SCM), crucial for long-term persistence.The cocktail ...

In immune cells, scaffold proteins have an important role in the regulation of mitogen-activated protein kinase activation, calcium signalling, signalling downstream of innate immune receptors and ...

Errors in the in the ALK gene are one type of lung cancer biomarker. ALK stands for anaplastic lymphoma kinase. It was originally described in lymphoma, but most ALK-positive cancers are in non-small ...