Panel B describes the refined model of KRAS activation informed by the ... GEF guanine exchange factor, MEK mitogen-activated protein kinase kinase, MT mutant, Pi inorganic phosphate, P13K phospho ...

Olive oil bioactives, including MUFAs, polyphenols, and triterpenoids, modulate gene expression linked to insulin sensitivity ...

Pfizer Inc. (NYSE: PFE) today announced positive topline results from the progression-free survival (PFS) analysis of the Phase 3 BREAKWATER study of ...

In October 2024, Lutris successfully completed enrollment in the international phase 2 trial of LUT014 in patients with metastatic colorectal cancer (mCRC) treated with EGFRi therapy who develop ...

Inflammatory pathways like the nuclear factor-kappa B (NF-κB), cyclooxygenase (COX), and mitogen-activated protein kinase (MAPK ... and the activation of the NLRP3 inflammasome.

We found that the CMA caused by DOX is associated with the upregulation of FOXOs and “atrogenes,” the activation of transient ... phosphoinositide 3-kinase; p38 MAPK, p38 mitogen-activated protein ...

During activation, quiescent PSC lose their intracellular ... have also been identified in recent years. Inhibition of mitogen-activated protein kinase (ERK, JNK and p38 kinase) signalling in PSC ...

Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase ... Constitutive ALK activity in cancers results in the activation of several downstream pathways that are shared with other tyrosine ...

Protein kinase C (PKC) is as a family of serine/threonine kinases that can be activated by Ca 2+, phospholipid and diacylglycerol. PKC plays an important role in oocyte maturation and activation.

retriever generates disease-specific transcriptional drug response signatures by merging transcriptional signatures over time, concentration, and cell-type. These signatures can then be matched to ...

A thermal stability-based proteomic analysis identifies cytoplasmic PEBP1 as a mediator of mitochondrial dysfunction-induced stress response, highlighting its potential role in cellular adaptation ...

Mitogen-activated protein kinases (MAPKs) in tomato plants have crucial functions of mediating responses to environmental cues, internal signals, defense mechanisms, cellular processes, and plant ...