Panel B describes the refined model of KRAS activation ... related kinase (ERK). AF6 denotes afadin, GAP GTPase-activating protein, GEF guanine exchange factor, MEK mitogen-activated protein ...

Olive oil bioactives, including MUFAs, polyphenols, and triterpenoids, modulate gene expression linked to insulin sensitivity ...

In October 2024, Lutris successfully completed enrollment in the international phase 2 trial of LUT014 in patients with metastatic colorectal cancer (mCRC) treated with EGFRi therapy who develop ...

Pfizer Inc. (NYSE: PFE) today announced positive topline results from the progression-free survival (PFS) analysis of the Phase 3 BREAKWATER study of ...

Therefore, activation or inhibition of these signaling pathways could regulate the M1/M2 ratio ... lipopolysaccharide; MAPK, mitogen-activated protein kinase; NF‐κB, nuclear factor kappaB; PDGF, ...

Multiple signaling pathways, including Notch ... Extracellular regulated protein kinases; MAPK, Mitogen-activated protein kinase; MMP, Metalloproteinase; IL-6R, interleukine-6 receptor; IL-1βR, ...

Another confounder is the activation ... Signalling pathways that are responsible for PSC inactivation (reversal to a relatively quiescent phenotype) have also been identified in recent years.

Anaplastic lymphoma kinase (ALK) is a receptor tyrosine ... Constitutive ALK activity in cancers results in the activation of several downstream pathways that are shared with other tyrosine ...

This important study demonstrates the potential of synthetic gene circuits to detect and target aberrant RAS activity in cancer cell lines. The circuit design is novel and the evidence supporting the ...

Ignite Proteomics announces the publication of a significant study in the British Journal of Cancer titled “Functional activation of the ...

This “bi-kinase module” sensitises the NADPH oxidase to calcium and enables synergistic activation of this enzyme ... human cell cultures were used in which the plant signalling pathway was ...