The adult mammalian myocardium has a robust intrinsic regenerative capacity because of the presence of cardiac stem cells (CSCs). Despite being mainly composed of terminally differentiated ...

The central objective of this proposal is to “turn back the clock” of the myocyte cell cycle for myocardial regeneration. Previous research observations of Zhang’s lab suggest that mammalian ...

whereas myocyte maintenance and replacement depends, in turn, on the progeny of the CSCs. 5 Thus, the dialogue between terminally differentiated myocytes and the stem or progenitor cells is the ...