The company is exploring the potential of targeting integrins to achieve better myocyte tropism compared ... of Arrowhead's TRiM (Targeted RNAi Molecule) platform. As the company's first drug ...

Injecting old mice with an RNA molecule seems to reverse some signs of ageing — helping them to live longer, regrow hair and maintain their physical and mental abilities. Ageing studies in five ...

ZJU-Hangzhou Global Scientific and Technological Innovation Canter, Zhejiang University, Hangzhou, Zhejiang 311215, China College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, ...

This important Research Advance presents convincing evidence on the neuroprotective effects of reserpine in a well-established model of retinitis pigmentosa (P23H-1). This study builds on previous ...

Cardiovascular and cardiometabolic diseases are leading causes of morbidity and mortality worldwide, driven in part by chronic inflammation. Emerging research suggests that the bone marrow ...

A higher number means they are more similar. Molecular Descriptors: Every molecule has specific properties that define its behavior in the body, such as: Molecular Weight: The weight of the molecule, ...

Mitophagy is a type of autophagy that can selectively eliminate damaged and depolarized mitochondria to maintain mitochondrial activity and cellular homeostasis. Several pathways have been found to ...

Endothelial cells are, by number, one of the most abundant cell types in the heart and active players in cardiac physiology and pathology. Coronary angiogenesis plays a vital role in maintaining ...

AI molecular design tool for de novo design, scaffold hopping, R-group replacement, linker design and molecule optimization.