In a phase 2 registrational trial, zenocutuzumab showed durable anti-tumor activity across a variety of NRG1 fusion-positive cancer types, providing a new treatment for patients with few ...

We developed an endothelial cell-specific polygenic risk score for coronary artery disease (CAD), which quantifies a currently immeasurable axis of CAD risk. This tool identifies patients who are ...

Multi-omic single-cell and spatial analyses of lung cancer brain metastases from multiple cohorts identify high levels of chromosomal instability and a neural-like profile in brain metastases ...

This Review discusses the evolving landscape of biomedical HIV prevention technologies for women in Africa—who bear a disproportionate burden of new infections—and the cost-effectiveness ...

The criteria for consideration of translational and clinical research in Nature Medicine are originality, timeliness and impact on improving human health by addressing unmet clinical needs.

Base editing, antisense oligonucleotides and siRNA therapies that target low-density lipoprotein and the genes encoding molecules that regulate it are being tested in several clinical trials.

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