Pyramidal-neuron dendrites contain voltage-gated channels ... with the large local depolarization causing significant activation of voltage-gated conductances. It is important to understand ...

Around the cell's resting potential the block is in place; upon excitation and, hence, the neuron depolarization of the cell's membrane, the block is released and the channel activated by glutamate ...

Figure 1: Mitochondrial inhibitors enhance glutamate-stimulated mitochondrial membrane depolarization. Figure 5: FCCP does not block glutamate-stimulated increases in NOS activity. We have shown ...