Mitochondrial defects, however, are associated with the development of diseases such as type 2 diabetes. Patients who suffer from this disorder are unable to produce enough insulin or use the insulin ...

Mitochondrial damage is common in metabolic diseases like Diabetes, affecting insulin production and function in patients. Diabetics’ insulin-producing β-cells have abnormal mitochondria, impairing ...

In patients with frequent severe hypoglycaemic events, allogeneic pancreatic islet transplantation results in better glycaemic control than insulin therapy alone, enhances quality of life, and reduces ...

Mitochondria are essential for generating energy that fuels cells and helps them function. Mitochondria are essential for generating energy that fuels cells and helps them function.

Our study found that demethylase TET2 was localized in the islets of mice, and the expression level increased with age. TET2 knockout in pancreatic β cells can hypermethylate PTEN, up-regulate MOF and ...

TET2 is upregulated during aging, high-fat diet feeding, high glucose on rat beta cell line INS1E, and in leptin receptor deficient (db/db) mice islets. This was not found ... staining comparing young ...

“The clinical data are highly promising for patients and provide the first evidence in humans for overcoming allogeneic and autoimmune rejection with pancreatic islet cell transplantation in type 1 ...