Functional subpopulations of β-cells emerge to control pulsative insulin secretion in the pancreatic islets of mice through calcium oscillations.

Targeting mitochondrial retrograde signaling may therefore be promising in the treatment or prevention of metabolic disorders ...

Mitochondria play a crucial role in cellular energy production, and their dysfunction has long been linked to metabolic ...

University of Michigan researchers found that mitochondrial dysfunction triggers a stress response that prevents pancreatic β ...

Reversing mitochondrial damage could help cure diabetes Regardless of the cell type, the researchers found that damage to the ...

Mitochondria are essential for generating energy that fuels cells and helps them function. Mitochondrial defects, however, ...

Conceptual diagram summarizing the central experiment comparing cell death in amyloid-β treated neuronal cells with and without pancreatic β cell culture supernatant. Pancreas cells may produce ...

require lifelong immunosuppression to prevent rejection of the graft and potential recurrence of the autoimmune process that might again destroy pancreatic islet β-cells. Immunosuppressive ...

Activation of both endogenous and exogenous ligands of pattern-recognition receptors can induce islet inflammation and death of pancreatic β cells Amplification of insulitis might depend on a ...

(B) Total β-cell area per pancreas for WT animals (n=3) and animals with CF (n=3). (C) Quantification of islet size in WT (n=3) and CF (n=3) pancreas. (D) Frequency distribution of individual ...