Loss of hormone secretion, particularly of ACTH, and to a lesser extent TSH, can rapidly become life-threatening and requires urgent replacement therapy. Acute, severe hypopituitarism should be ...

Additionally, transcriptome sequencing was employed to identify potential signaling pathways associated with PMAIP1. Mechanistic studies involved a series of rescue experiments to elucidate the ...

The tissue was also subjected to immunohistochemical analysis exclusively for adenohypophyseal hormones (transcription factor assessment unavailable): GH, prolactin, TSH, ACTH, FSH, LH, alpha-subunit, ...

Johnson & Johnson Innovative Medicine considers that the technology is unlikely to be used at this point in the treatment pathway. If NHS organisations wish to consider niraparib for this indication, ...