GlobalData on MSN10h
FDA approves Gomekli as first neurofibromatosis drug for adults
The US Food and Drug Administration (FDA) has approved SpringWorks Therapeutics’ Gomekli (mirdametinib) to treat ...
News Medical on MSN13d
A new therapeutic target for a lethal form of heart failure: ALPK2
Heart failure with preserved ejection function is a lethal form of heart failure, with few effective treatments. A team from ...
High levels of adrenomedullin found to promote obesity-associated insulin resistance
Adrenomedullin (ADM) inhibits endothelial insulin signaling, contributing to obesity-associated insulin resistance, according ...
Monthly Prescribing Reference1d
Encapsulated Rapamycin Fast Tracked for Familial Adenomatous Polyposis
The Fast Track designation is supported by data from a phase 2 trial that evaluated eRapa in 30 adult patients with FAP.
News Medical on MSN20h
Targeting PAK5 could offer new therapeutic approach for endometriosis
Endometriosis, a prevalent gynecological condition, is characterized by the growth of endometrial-like tissues outside the ...
Nature19d
Mitogen-Activated Protein Kinase Signaling Pathways and Inhibitors
Mitogen-Activated Protein Kinase (MAPK) signaling pathways play a crucial role in various cellular processes, including growth, differentiation, and response to stress. These pathways are ...
EurekAlert!14d
Schematic illustration of Z526's effects on cancer-associated cachexia. (IMAGE)
In cancer-associated cachexia, elevated TNF-α and IL-6 exacerbate muscle and fat loss by regulating multiple metabolic signaling pathways, which could be ameliorated by Z526's suppression of NF-κB ...
New Therapeutic Target Discovered for Lethal Form of Heart Failure
Researchers discovered that ALPK2, a heart-specific enzyme, may protect against HFpEF by activating TPM1 in heart muscle ...