Using a series of more than 1,000 X-ray snapshots of the shapeshifting of enzymes in action, researchers at Stanford ...

An enzyme called cyclin-dependent kinase 2 (CDK2) regulates the cell cycle and may have the potential to drive therapeutic ...

Researchers have revealed new details about the CRISPR-Cas5-HNH/Cascade complex, a variant of the type I-E CRISPR-Cas system, ...

A temporally resolved CRISPR-Cas9 screen reveals DAC-induced DNA damage drives trans-cell cycle cytotoxicity that depends on ...

The mechanism of enzyme catalysis is similar in principle to ... which involves cholesterol and vitamin K. Protein kinase R-like endoplasmic reticulum kinase-phosphorylated adenylosuccinate ...

On the other hand, mechanisms of acquired resistance to 'pathway-targeted' drugs, such as the various clinically active kinase inhibitors, have been somewhat more straightforward to elucidate and ...

The researchers investigated the effect of different conducting polymers (PANI, PPy, and poly(3,4-ethylenedioxythiophene) (PEDOT)) on the mechanism of CP@CdS core-shell nanorods. The results show that ...

"These findings illuminate a critical mechanism that connects local synaptic ... This research focuses on the cAMP-response element binding protein (CREB), a transcription factor known to regulate ...

The lab recently determined that what is important is not formation of the fusion, but that the formation results in an increase of the amount of PRKACA—the catalytic subunit of protein kinase A ...

Given that proteins display large ... entropic bottleneck for enzyme catalysis. To shed light on this question, we studied the nature of the enzymatic transition state for the phosphoryl-transfer step ...

School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland 4072, Australia ...