This important study demonstrates the potential of synthetic gene circuits to detect and target aberrant RAS activity in cancer cell lines. The circuit design is novel and the evidence supporting the ...

Following publication, concerns were raised regarding the integrity of the images in the published figures. Specifically, unexpected similarity was detected between western blot images presented in ...

as a novel molecule that plays a crucial role in the pathogenesis of pressure overload–induced cardiac hypertrophy, by modulating GSNOR levels, thereby demonstrating significant therapeutic potential.

Cardiac hypertrophy is the abnormal enlargement, or thickening, of the heart muscle, resulting from increases in cardiomyocyte size and changes in other heart muscle components, such as ...

Department of Applied Biology and Chemical Technology, State Key Laboratory of Chemical Biology and Drug Discovery, Hong Kong Polytechnic University, Hong Kong 999077, China ...

To address these clinical challenges, this paper proposes a novel deep learning approach for the non-invasive detection of adenoid hypertrophy using heartlung sounds. Firstly, we established a ...

The carboxyl terminus of Hsc70-interacting protein (CHIP) is pivotal for managing misfolded and aggregated proteins via chaperone networks and degradation pathways. In a preclinical rodent model of ...

Sustained exposure to pathological stress stimulates the heart to hypertrophy ... Cyclic GMP and protein kinase G (PKG) are intrinsic brake systems inhibiting several hypertrophic cascades.

1 Inner Mongolia Key Laboratory of Disease-Related Biomarkers, The Second Affiliated Hospital, Baotou Medical College, Baotou, China 2 School of Basic Medicine, Baotou Medical College, Baotou, China ...

They discovered that the protein Hmga1 plays a key role in heart regeneration in zebrafish. In mice, this protein was able to restore the heart by activating dormant repair genes without causing ...

Randall Centre for Cell and Molecular Biophysics, and British Heart Foundation Centre of Research Excellence, King’s College London, London SE1 1UL, United Kingdom ...