Here we show that activation of the lactate receptor HCAR1 in colorectal tumor cells leads to the recruitment of immunosuppressive PMN-MDSCs to tumors, thereby impairing anti-tumor immunity and ...

When a child develops a brain tumor, early diagnosis is essential. Alan Cohen, M.D., director of pediatric neurosurgery at Johns Hopkins Children’s Center, shares the most common signs and symptoms ...

The TP53 gene is a gene that is mutated in many cancers. It is the most common gene mutation found in cancer cells. A tumor-suppressor gene, TP53 codes for a protein that inhibits the development and ...

The tissue adjacent to a tumor behaves differently than areas farther away: The tumor’s cancerous cells influence their surroundings, blocking the body’s immune defenses and creating a sort of haven ...

Researchers from Iwate Medical University and Tohoku University have revealed that it is possible to predict cancer relapse and treatment response by measuring circulating tumor DNA (ctDNA), in ...

According to her mom, Penny was diagnosed with Wilms tumor, which is cancer in the kidneys, last April. The Children's Hospital says 75% of cases occur in kids below the age of 5. Penny's mom says ...

We discuss the challenges such as immunosuppressive microenvironment, tumor heterogeneity, and physical barriers that limit CAR-T efficacy. Emerging strategies, such as logic-gated and dual-targeting ...

The main goal of surgery is to remove the entire Wilms tumor in one piece, if possible. This is important because Wilms tumors tend to be fragile. Cutting into them makes it more likely that some ...

The most important factors in determining a child’s outlook are the stage and histology of the tumor. (Histology refers to how the cancer cells look under the microscope – see What Are Wilms Tumors?) ...

Wilms tumor (also called nephroblastoma) is the most common type of kidney cancer in children. About 9 of 10 kidney cancers in children are Wilms tumors. These cancers are different from adult kidney ...