Aberrant activation of the Ras/Raf/MAPK/ERK kinase/extracellular signal-regulated kinase cascade and the VEGF pathway are commonly observed in breast cancer cells leading to malignant cell ...

Drug major Pfizer Inc. (PFE) announced Monday positive topline results from the progression-free survival or PFS analysis of the ...

Pfizer Inc. (NYSE: PFE) today announced positive topline results from the progression-free survival (PFS) analysis of the Phase 3 BREAKWATER study of ...

Pfizer Inc. today announced positive topline results from the progression-free survival (PFS) analysis of the Phase 3 BREAKWATER study of BRAFTOVI® (encorafenib) in combination with cetuximab ...

Cigarette smoking is a well-known risk factor of colorectal cancer (CRC), but the mechanism of how ... lenta and TDCA, impaired colonic epithelium and increased activation of MAPK/ERK and ...

inspired by the promise of targeting cancer-associated molecular pathways upstream of other targets like RAS/ERK MAPK, which drive cellular proliferation and survival. According to BridgeBio and ...

Objective Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer with limited ... by restraining the p-MET/p-ERK cascade but not the AKT/mTOR signalling. Concomitant activation ...

This important study demonstrates the potential of synthetic gene circuits to detect and target aberrant RAS activity in cancer cell lines. The circuit design is novel and the evidence supporting the ...

Feb. 7, 2025 — Pancreatic cancer patients may benefit from future precision treatments as a new study shows how some tumors may potentially be more susceptible to ... Personalized Cancer ...

CIRBP Family, Tumors, Molecular Mechanisms, RNA-Binding Proteins, Cellular Stress Share and Cite: Cai, Y. , Wang, T. and Zhan ...