News Medical1d
New insight into gut stem cell aging
A recent study led by Associate Professor Takuya Yamamoto and Researcher May Nakajima-Koyama has revealed that maintaining a delicate balance between interferon-gamma (IFN-γ) and extracellular ...
Scientific Research Publishing2d
Molecular Mechanisms of the CIRBP Family in Tumors: Current Status and Future Perspectives ()
CIRBP Family, Tumors, Molecular Mechanisms, RNA-Binding Proteins, Cellular Stress Share and Cite: Cai, Y. , Wang, T. and Zhan ...
eLife3d
Synthetic gene circuits that selectively target RAS-driven cancers
This important study demonstrates the potential of synthetic gene circuits to detect and target aberrant RAS activity in cancer cell lines. The circuit design is novel and the evidence supporting the ...
eLife8d
Intrinsic bioenergetic adaptations compensate for reduced mitochondrial content in HER2-driven mammary tumors
However, mechanistic studies to support the conclusion that mitochondrial function is increased in the tumours remain incomplete and would benefit from experiments that would directly interrogate ...
Armed robbery in Revesby11d
Pfizer's BRAFTOVI Regimen Boosts Survival in Phase 3 Trial
Pfizer Inc. (NYSE: PFE) today announced positive topline results from the progression-free survival (PFS) analysis of the Phase 3 BREAKWATER study of ...
PipelineReview.com12d
Pfizer’s BRAFTOVI® Combination Regimen Significantly Improved Progression-Free Survival and Overall Survival in Phase 3 BREAKWATER Trial
NEW YORK, NY, USA I 03, 2025 I Pfizer Inc. (NYSE: PFE) today announced positive topline results from the progression-free survival (PFS) analysis of ...
Pfizer: BRAFTOVI Combination Regimen Shows Significant Improvement In PFS In Phase 3 Trial In MCRC
Drug major Pfizer Inc. (PFE) announced Monday positive topline results from the progression-free survival or PFS analysis of the ...
Frontiers17d
Phase-dependent iron depletion differentially regulates the niche of intestinal stem cells in experimental colitis via ERK/STAT3 signaling pathway
1 Radiation Oncology Key Laboratory of Sichuan Province, Sichuan Cancer Hospital & Institute ... were used to examine the influence of iron depletion in vitro. Signaling pathway and inflammatory ...
Cayman Compass18d
HSA hosts annual World Cancer Day Event: Empowering Progress in Cancer Care Pathways
This year’s theme, “Empowering Progress: New Frontiers in Cancer Care Pathways,” highlights some of the latest advancements and collaborative efforts in cancer care within the Cayman Islands.
C&EN18d
Blocking the p38 MAPK Signaling Pathway in the Rat Hippocampus Alleviates the Depressive-like Behavior Induced by Spinal Cord Injury
Department of Neurosurgery, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical College, No. 152 Aiguo Road, Nanchang, Jiangxi 330006, China Department of ...
Business Standard23d
Canada PR: 4 new permanent residency pathways to be introduced in 2025
Want to apply for Canada PR? The country is set to introduce four new permanent residency (PR) pathways in 2025, even as the government plans to reduce its PR targets from 485,000 to 465,000, ...
Frontiers24d
hERG activators exhibit antitumor effects in breast cancer through calcineurin and β-catenin-mediated signaling pathways
Background: Breast cancer remains a leading cause of mortality among women ... drug candidates with new mechanisms of action by targeting alternative signaling pathways. While hERG channel is ...