Structure of the influenza virus A H5N1 nucleoprotein: …
Here, we report the 3.3-Å crystal structure of H5N1 NP, which is composed of a head domain, a body domain, and a tail loop.
H5N1 genetic structure - Wikipedia
The genetic structure of H5N1, a highly pathogenic avian influenza virus (influenza A virus subtype H5N1), is characterized by a segmented RNA genome consisting of eight gene segments that encode for various viral proteins essential for replication, host …
THE BIOLOGY OF INFLUENZA VIRUSES - PMC - PubMed Central …
The influenza viruses are characterized by segmented, negative-strand RNA genomes requiring an RNA-dependent RNA polymerase of viral origin for replication. The particular structure of the influenza virus genome and function of its viral proteins ...
Influenza Virus: The Biology of a Changing Virus - PMC
H5N1 binds type II pneumocytes and macrophages of the lower respiratory tract in humans [92, 94, 101]. H5N1 infection of ciliated cells in HTBE cell culture with limited cell-to-cell spread and of human nasopharyngeal, adenoid, and tonsillar ex vivo cell cultures has been shown .
2Q06: Crystal structure of Influenza A Virus H5N1 Nucleoprotein
May 21, 2007 · The nucleoprotein (NP) of the virus binds the RNA genome and acts as a key adaptor between the virus and the host cell. It, therefore, plays an important structural and functional role and represents an attractive drug target. Here, we report the 3.3-A crystal structure of H5N1 NP, which is composed of a head domain, a body domain, and a tail loop.
Structure of the influenza virus A H5N1 nucleoprotein ... - PubMed
The nucleoprotein (NP) of the virus binds the RNA genome and acts as a key adaptor between the virus and the host cell. It, therefore, plays an important structural and functional role and represents an attractive drug target. Here, we report the 3.3-A crystal structure of H5N1 NP, which is composed of a head domain, a body domain, and a tail loop.
Here, we report the 3.3-Å crystal structure of H5N1 NP, which is composed of a head domain, a body domain, and a tail loop.
H5N1 avian influenza virus: an overview - SciELO - Brasil
Avian influenza virus (H5N1) emerged in Hong Kong in 1997, causing severe human disease. In recent years, several outbreaks have been reported in different parts of Asia, Europe and Africa, raising concerns of dissemination of a new and highly lethal influenza pandemic.
Structure and Receptor Specificity of the Hemagglutinin from an H5N1 …
The hemagglutinin (HA) structure at 2.9 angstrom resolution, from a highly pathogenic Vietnamese H5N1 influenza virus, is more related to the 1918 and other human H1 HAs than to a 1997 duck H5 HA. Glycan microarray analysis of this Viet04 HA reveals an avian α2-3 sialic acid receptor binding preference.
Receptor binding, structure, and tissue tropism of cattle-infecting ...
4 days ago · The ongoing circulation of 2.3.4.4b H5N1 avian influenza virus, highlighted by recent cattle outbreaks, poses a significant threat to both animal and public health. Structural insights uncover the molecular mechanisms behind the receptor-binding properties of bovine H5N1 to human and bovine tissues, providing critical insights …