In the physical sciences, a partition coefficient (P) or distribution coefficient (D) is the ratio of concentrations of a compound in a mixture of two immiscible solvents at equilibrium. This ratio is therefore a comparison of the solubilities of the solute in these two liquids.

Two compounds may both have log P values equal to -1, indicating that they are more soluble in aqueous than organic solvents; but they may nonetheless have very different solubility limits in aqueous buffers.

LogP is used in the pharmaceutical/biotech industries to understand the behavior of drug molecules in the body. Drug candidates are often screened according to logP, among other criteria, to help guide drug selection and analog optimization.

LogP is an important component of Lipinski’s Rule of 5 recommendations which predicts the drug-likeness of a new synthetic compound. According to Lipinski’s Rule of 5, an oral drug should have a LogP value <5, ideally between 1.35-1.8 for good oral and intestinal absorption.

Sep 3, 2022 · LogP gives you an indication of how well the molecule will partition into the organic elution solvent. The higher the logP, the more likely the compound will partition from the SLE phase into the organic elution solvent like dichloromethane, ethyl acetate or MTBE.

LogP measures the logarithm of ration between the concentration of a compound in a non-polar solvent and in water. It is common practice to measure this using octanol (PubChem 2003) as the non-polar solvent. Mathematically LogP is defined like \[\text{LogP} = \log \frac{[\text{Drug}]_{\text{non-polar}}}{[\text{Drug}]_{\text{water}}}\]

Jul 7, 2023 · Enter the concentration of organic and aqueous partition into the calculator to determine the partition coefficient and LogP.

LogP is defined as the partition coefficient of a molecule between aqueous and lipophilic phases usually considered as octanol and water. It is determined experimentally by dissolving the …

Based on acid dissociation reactions, we can introduce the concept of a partition coefficient for cationic and anionic species and for neutral species. The following gives the definition of partition and distribution coefficients for ionized and unionized species.

Oct 29, 2024 · LogP and logD are important values to consider during drug design as both give insight to the lipophilicity and hydrophilicity of compounds.