Our study provides novel insight into the primary–quaternary structure relationship of human tau and suggests that 3R‐tau oligomers may be an important target for future development of …

These PBs primarily consist of hyperphosphorylated tau protein, with tau protein presenting as two major bands at 60 and 64 kDa and a variable, minor band at 69 kDa. Filamentous tau …

Jan 7, 2020 · Although normal human brains express 6 tau isoforms in equal ratio with 3 or 4 microtubule-binding repeat domains (3R and 4R), tau inclusions from different human …

May 12, 2021 · CTE and AD were both observed to contain mixed 3R and 4R tau isoforms, with 4R predominating in mild disease and 3R increasing proportionally as pathological severity …

Sep 29, 2021 · Six tau isoforms are expressed in the adult human brain; three isoforms have three microtubule-binding repeats (3R) and three isoforms have four repeats (4R) 6. On the …

We compared the clinical characteristics of 3 repeat (3R) and 4 repeat (4R) tau-positive cases (tauopathies) presenting as behavior variant frontotemporal dementia (bv-FTD). We identified …

To explore this, we have compared the phenotypes induced by the 0N3R and 0N4R isoforms in Drosophila. Expression of the 3R isoform causes more profound axonal transport defects and …

The predominant aggregation of certain MAPT (tau gene) isoforms, either the 4-repeat (4R tau) or the 3-repeat (3R tau) isoform has been widely described in tauopathies. Alterations of the 4R …

Sep 1, 2017 · All six isoforms of human tau have traditionally been considered to be functionally similar. We show here that there are isoform specific differences in the phenotypes induced by …

Feb 22, 2020 · Here we describe a tau RT-QuIC assay (K12 RT-QuIC) that, using a C-terminally extended recombinant 3R tau substrate (K12CFh), enables sensitive detection of Pick …