LogP is an important component of Lipinski’s Rule of 5 recommendations which predicts the drug-likeness of a new synthetic compound. According to Lipinski’s Rule of 5, an oral drug should have a LogP value <5, ideally between 1.35-1.8 for good oral and intestinal absorption.

Lipinski's rule of five, also known as Pfizer's rule of five or simply the rule of five (RO5), is a rule of thumb to evaluate druglikeness or determine if a chemical compound with a certain pharmacological or biological activity has chemical properties and physical properties that would likely make it an orally active drug in humans.

In the physical sciences, a partition coefficient (P) or distribution coefficient (D) is the ratio of concentrations of a compound in a mixture of two immiscible solvents at equilibrium. This ratio is therefore a comparison of the solubilities of the solute in these two liquids.

Sep 3, 2022 · LogP is an important component of Lipinski’s Rule of 5 recommendations which predicts the drug-likeness of a new synthetic compound. According to Lipinski’s Rule of 5, an oral drug should have a LogP value 5, ideally between 1.35-1.8 for good oral and intestinal absorption.

LogP is the log of the partition coefficient of a solute between octanol and water, at near infinite dilution. LogP is widely used in drug discovery and development as an indicator of potential utility of a solute as a drug.

The rule of 5 indicates that poor absorption is more likely to occur when there are more than (i) 5 hydrogen-bond donors, (ii) 10 (5 × 2) hydrogen-bond acceptors, (iii) a molecular weight greater than 500 (5 × 100), and (iv) a calculated Log P (cLogP) greater than 5.

LogP is used in the pharmaceutical/biotech industries to understand the behavior of drug molecules in the body. Drug candidates are often screened according to logP, among other criteria, to help guide drug selection and analog optimization.

Due to the importance of the drug lipophilicity, logP is a component of the Lipinski rule of five. 1. LogP is defined as the partition coefficient of a molecule between aqueous and lipophilic …

Sep 13, 2023 · LogP (Partition Coefficient) < 5: LogP represents the octanol-water partition coefficient, which measures a compound’s lipophilicity. A logP value not exceeding 5 indicates an appropriate balance between hydrophilicity and lipophilicity for efficient drug absorption.

Jun 13, 2018 · Lipinski’s “rule of five”, 1 very well known by medicinal chemists, has been defined as a set of rules, based on the number 5 -hence its name-, to evaluate the “drug-likeness” of a given molecule. The rules are: – The molecule should have no more than 5 H-bond donors and 10 H-bond acceptors (i.e. N or O atoms).