
Plasma membrane translocation of trimerized MLKL protein is …
Dec 8, 2013 · By generating different MLKL mutants, we demonstrated that the plasma membrane localization of trimerized MLKL is critical for mediating necroptosis. Importantly, we found that the membrane...
Treatment with mRNA coding for the necroptosis mediator MLKL …
Aug 24, 2018 · We demonstrate that intratumor administration of mRNA encoding MLKL elicits a potent antitumor T cell response—involving T cells directed against tumor neo-antigens—even in tumors that are...
The gasdermins: a pore-forming protein family expressed in the ...
Proliferating human keratinocytes and the SCC cell line A431 express GSDMA protein (80, 81), but its mRNA expression is strongly induced upon keratinocyte differentiation, suggesting a particularly important role in the outer epidermal layers .
Targeting regulated cell death (RCD) with naturally derived ...
Jan 1, 2025 · Recent studies have highlighted the significant role of necroptosis in tumorigenesis and tumor progression. Necroptosis is a controlled type of necrosis that relies on the phosphorylation of Mixed-lineage kinase-like protein (MLKL) by Receptor-interacting serine/threonine kinase 1 (RIPK1) and RIPK3 [187].
Mixed lineage kinase domain like pseudokinase - Wikipedia
A unique neurodegenerative disease has been reported in association with a homozygous frameshift mutation, rs561839347, in MLKL that causes replacement of part of the C-terminal pseudokinase domain with a 21-residue sequence of random amino acids.
Engineered hypoxia-responsive albumin nanoparticles mediating …
Jan 11, 2025 · In this study, we develop an azocalix [4]arene-modified supramolecular albumin nanoparticle, that co-delivers hydroxychloroquine and a mitochondria-targeting photosensitizer, designed to induce...
A-431 - CRL-1555 - ATCC
A-431 is a cell line exhibiting epithelial morphology that was isolated from the epidermis of an 85-year-old female patient with epidermoid carcinoma. This cell line is one of a series of cell lines established from solid tumors by D.J. Giard, et al. and can be used in cancer, toxicology, and immuno-oncology research.
Inhibition of MLKL-dependent necroptosis via downregulating …
Apr 20, 2021 · In this study, we aim to elucidate the molecular mechanism underlying hypoxic preconditioning that inactivates MLKL-dependent neuronal necroptosis after tGCI. Transient global cerebral ischemia was induced by the four-vessel occlusion method.
IPMK antibody (30161-1-AP) | Proteintech - ptglab.com
30161-1-AP targets IPMK in WB, IF/ICC, ELISA applications and shows reactivity with Human samples. PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.
Analysis of the N-terminal region of human MLKL, as well as two ...
Jan 22, 2016 · We show that mixed lineage kinase domain-like (MLKL) isoform 2, which lacks the pseudokinase domain and activation loop phosphorylation sites, is a more potent activator of cell death compared with MLKL isoform 1. Both MLKL isoforms are expressed in human monocyte-derived macrophages.