Plasma membrane translocation of trimerized MLKL protein is …
Dec 8, 2013 · By generating different MLKL mutants, we demonstrated that the plasma membrane localization of trimerized MLKL is critical for mediating necroptosis. Importantly, we …
Treatment with mRNA coding for the necroptosis mediator MLKL …
Aug 24, 2018 · We demonstrate that intratumor administration of mRNA encoding MLKL elicits a potent antitumor T cell response—involving T cells directed against tumor neo-antigens—even …
The gasdermins: a pore-forming protein family expressed in the ...
Proliferating human keratinocytes and the SCC cell line A431 express GSDMA protein (80, 81), but its mRNA expression is strongly induced upon keratinocyte differentiation, suggesting a …
Targeting regulated cell death (RCD) with naturally derived ...
Jan 1, 2025 · Recent studies have highlighted the significant role of necroptosis in tumorigenesis and tumor progression. Necroptosis is a controlled type of necrosis that relies on the …
Mixed lineage kinase domain like pseudokinase - Wikipedia
A unique neurodegenerative disease has been reported in association with a homozygous frameshift mutation, rs561839347, in MLKL that causes replacement of part of the C-terminal …
Engineered hypoxia-responsive albumin nanoparticles mediating …
Jan 11, 2025 · In this study, we develop an azocalix [4]arene-modified supramolecular albumin nanoparticle, that co-delivers hydroxychloroquine and a mitochondria-targeting …
A-431 - CRL-1555 - ATCC
A-431 is a cell line exhibiting epithelial morphology that was isolated from the epidermis of an 85-year-old female patient with epidermoid carcinoma. This cell line is one of a series of cell lines …
Inhibition of MLKL-dependent necroptosis via downregulating …
Apr 20, 2021 · In this study, we aim to elucidate the molecular mechanism underlying hypoxic preconditioning that inactivates MLKL-dependent neuronal necroptosis after tGCI. Transient …
IPMK antibody (30161-1-AP) | Proteintech - ptglab.com
30161-1-AP targets IPMK in WB, IF/ICC, ELISA applications and shows reactivity with Human samples. PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20°C. Stable for …
Analysis of the N-terminal region of human MLKL, as well as two ...
Jan 22, 2016 · We show that mixed lineage kinase domain-like (MLKL) isoform 2, which lacks the pseudokinase domain and activation loop phosphorylation sites, is a more potent activator of …