Mar 18, 2022 · We identified paclitaxel as a universal adjuvant that efficiently potentiated ADCP by a variety of anticancer antibodies in multiple cancers. Rather than eliciting cytotoxicity on cancer cells, paclitaxel polarized macrophages toward a state with enhanced phagocytic ability.

ADCP is the mechanism by which antibody-opsonized target cells activate the FcγRs on the surface of macrophages to induce phagocytosis, resulting in internalization and degradation of the target cell through phagosome acidification.

Antibody-dependent cellular cytotoxicity & phagocytosis (ADCC & ADCP) InvivoGen offers convenient ADCC and ADCP cellular assays to screen monoclonal antibody effector functions. ADCC and ADCP are two major modes of action of therapeutic monoclonal Abs (mAbs).

In this review, we discuss the properties of Fc receptors, antibodies, and effector cells that influence ADCP. We also provide and interpret evidence from studies that support a potential role for ADCP in either inhibiting or enhancing viral infection.

Antibody-dependent cellular phagocytosis (ADCP) is a cellular process by which effector cells with phagocytic potential, such as monocytes and macrophages, can internalize target cells.

Antibody-dependent cellular phagocytosis (ADCP) is a mechanism by which macrophages contribute to antitumor potency of monoclonal antibodies. Herein, we studied the NK cell independent effect of elotuzumab on tumor-associated macrophages using a xenograft tumor model deficient in NK and adaptive immune cells.

cellular phagocytosis (ADCP), which relies on macrophages to attack and devour tumor cells following antibody binding, is a potentially useful mechanism of action (MOA) for antibody drug devel-opers and vaccine makers to consider in determining product efficacy.

Linking of FcγRs on macrophages triggers the process of antibody-dependent cellular phagocytosis (ADCP), where antibody-opsonized target cells are internalized in phagosomes and degraded through the process of phagosome maturation and acidification.

Aug 1, 2024 · ADCP is a cellular process by which antibody-opsonized targets (including pathogens and cells) are engulfed by phagocytes. In ADCP, phagocytes are normally effector immune cells with phagocytic potential, such as macrophages, monocytes, and dendritic cells as well as neutrophils (Tay et al., 2019). They can internalize antibody-opsonized ...

May 1, 2019 · ADCP is the mechanism by which antibody-opsonized target cells activate the FcγRs on the surface of macrophages to induce phagocytosis, resulting in internalization and degradation of the target cell through phagosome acidification.