Aug 14, 2023 · ADH binds to V receptors on vascular smooth muscle and activates G protein. G activates phospholipase C (PLC), which results in the production of inositol triphosphate (IP-3) as well as diacylglycerol (DAG) from the cell membrane.

G proteins, also known as guanine nucleotide-binding proteins, are a family of proteins that act as molecular switches inside cells, and are involved in transmitting signals from a variety of stimuli outside a cell to its interior.

Human vasopressin, also called antidiuretic hormone (ADH), arginine vasopressin (AVP) or argipressin, [5] is a hormone synthesized from the AVP gene as a peptide prohormone in neurons in the hypothalamus, [6] and is converted to AVP.

Autosomal dominant hypocalcemia (ADH) is characterized by hypocalcemia, inappropriately low serum parathyroid hormone concentrations and hypercalciuria. ADH is genetically heterogeneous with ADH type 1 (ADH1), the predominant form, being caused by germline gain-of-function mutations of the G-protein …

Aug 22, 2023 · ADH acts through a G-protein coupled receptor to increase the transcription and insertion of aquaporin – 2 channels to the apical membrane of the DCT and CD cells. Consequently, the permeability of the DCT and CD cells to water increases.

Although all three of these proteins are G-protein coupled receptors (GPCRs), activation of AVPR1A and AVPR1B stimulate phospholipase C, while activation of AVPR2 stimulates adenylate cyclase. These three receptors for vasopressin have unique tissue distributions.

The molecular mechanisms governing the G protein coupling selectivity of different members of the vasopressin receptor family were studied by using a combined molecular genetic/biochemical approach.

To understand ADH1B functions and consequences, we provide here a bioinformatic analysis of its gene regulation and molecular functions, literature review of studies focused on this gene, and a discussion regarding future research perspectives.

AVP acts on three different G protein-coupled receptors (V1a, V1b and V2) and, depending on the interaction, demonstrates different functions. They include vasoconstriction, glycogenolysis, modulation of ACTH synthesis, stimulation of water reabsorption, insulin secretion, regulation of blood pressure, etc.

Heterotrimeric G-proteins mainly relay the information from G-protein-coupled receptors (GPCRs) on the plasma membrane to the inside of cells to regulate various biochemical functions. Depending on the targeted cell types, tissues and organs, these signals modulate diverse physiological functions.