Nov 15, 2021 · Aryl hydrocarbon receptor (AHR) is an important regulator of skin barrier function. It also controls immune-mediated skin responses. The AHR modulates various physiological functions by acting as a sensor that mediates environment-cell interactions, particularly during immune and inflammatory respon …

In the skin, AHR is primarily expressed in the epidermis, including keratinocytes and Langerhans cells. By controlling responses to xenobiotic and environmental stressors, AHR is essential for preserving homeostasis.

Skin cells express the aryl hydrocarbon receptor (AHR), a ligand-activated transcription factor and sensor of environmental chemicals; at the same time, AHR ligands are abundant in skin from exogenous or endogenous sources.

Feb 1, 2017 · A plethora of molecules binds to AHR, causing down-stream gene induction. In this review we look at the skin. We review how man-made AHR ligands lead to skin toxicity, but also how AHR is involved in normal skin functions, and in situations of inflammation.

In this review, we introduce the role of AhR in various skin cells and its impact on skin barrier function. Furthermore, we explore the involvement of AhR in the development of various skin diseases, highlighting its potential as a therapeutic target for skin disorders.

In skin tissue, AhR plays an important role in maintaining skin homeostasis, such as environmental toxin metabolism, intracellular redox balance, response to ultraviolet (UV) light, diseases related to melanogenesis, regulation of immune …

Feb 15, 2009 · Here, we investigated the role of AhR in skin wound healing using either wild-type mice, mice heterozygously or homozygously deficient for the AhR gene. Our methods of full thickness dorsal skin wounding damaged both the epidermis and the underlying dermis.

Aug 23, 2021 · Aryl hydrocarbon receptor (AhR) has novel roles in skin homeostasis, regeneration, and hair cycling by controlling epidermal stem cells (EpdSCs) functions. During hair growth, AhR deficiency delays entry into anagen likely through loss of the self-renewal capacity and multipotentiality of AhR−/− hair follicle EpdSCs.

Jan 27, 2025 · Recent research has explored the substantial impact of AhR on skin homeostasis and related pathologies. As a multi-layered organ, the skin comprises multiple cell populations that express AhR. In this review, we introduce the role of AhR in various skin cells and its impact on skin barrier function.

The aryl hydrocarbon receptor (AHR) is expressed in a variety of skin cell types and contributes to skin homeostasis. Therapeutic targeting of the AHR in dermatology was first described for the treatment of inflammatory skin diseases using coal tar ointment.